Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 17/20 | 0.59 |
| ▸ | PARG | Q86W56 | 1/20 | 0.43 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146361 | 0.88 | GRM2 (0.62) | GRM2PARGPTAFRHTR2BKDM4E | |
| SCHEMBL10146311 | 0.84 | GRM2 (0.78) | GRM2PARGPTAFRHTR2BKDM4E | |
| SCHEMBL14992271 | 0.83 | GRM2 (0.56) | GRM2PARGPTAFRHTR2B | |
| SCHEMBL626487 | 0.83 | GRM2 (0.56) | GRM2PARGPTAFRHTR2BKDM4E | |
| SCHEMBL10145864 | 0.81 | GRM2 (0.59) | GRM2PARGPTAFRHTR2B | |
| SCHEMBL10145933 | 0.81 | GRM2 (0.58) | GRM2PARGPTAFRHTR2B | |
| SCHEMBL10146637 | 0.80 | GRM2 (0.64) | GRM2PARGPTAFRHTR2B | |
| SCHEMBL10146668 | 0.80 | GRM2 (0.70) | GRM2PARG | |
| SCHEMBL10146385 | 0.79 | GRM2 (0.62) | GRM2PARGPTAFRHTR2B | |
| SCHEMBL625526 | 0.79 | GRM2 (0.65) | GRM2PARGPTAFRHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |