Nanatinostat

Nanatinostat

SCHEMBL1014672

O=C(NO)c1cnc(N2CC3C(C2)C3NCc2ccc3cc(F)ccc3n2)nc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 20/20 1.00
HDAC4 P56524 20/20 1.00
HDAC1 Q13547 20/20 1.00
HDAC7 Q8WUI4 20/20 1.00
HDAC2 Q92769 20/20 1.00
HDAC10 Q969S8 20/20 1.00
HDAC11 Q96DB2 20/20 1.00
HDAC8 Q9BY41 20/20 1.00
HDAC6 Q9UBN7 20/20 1.00
HDAC9 Q9UKV0 20/20 1.00
HDAC5 Q9UQL6 20/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2D6 P10635 1/20 0.57
CYP2C19 P33261 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nanatinostat SCHEMBL22712412 1.00 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
Nanatinostat SCHEMBL29602260 1.00 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
Nanatinostat SCHEMBL22712415 1.00 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
Nanatinostat SCHEMBL22712419 1.00 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
Nanatinostat SCHEMBL29453926 1.00 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
Nanatinostat SCHEMBL25612092 1.00 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL1010499 0.90 HDAC1 (0.81) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL23510865 0.89 HDAC3 (0.81) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8242833 0.87 HDAC1 (0.77) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL1011927 0.87 HDAC3 (1.00) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260007676-A1 HDAC INHIBITORS FOR USE WITH NK CELL BASED THERAPIES VIRACTA THERAPEUTICS INC (US) 2026-01-08 US claimed
US-20260000672-A1 HISTONE DEACETYLASE INHIBITORS FOR USE IN IMMUNOTHERAPY VIRACTA SUBSIDIARY INC (US) 2026-01-01 US claimed
EP-4650005-A2 HISTONE DEACETYLASE INHIBITORS FOR USE IN IMMUNOTHERAPY Viracta Subsidiary, Inc. (US) 2025-11-19 EP claimed
EP-3484478-B1 HISTONE DEACETYLASE INHIBITORS FOR USE IN IMMUNOTHERAPY VIRACTA SUBSIDIARY INC (US) 2025-11-05 EP claimed
US-12427152-B2 HDAC inhibitors for use with NK cell based therapies VIRACTA THERAPEUTICS, INC. (CA) 2025-09-30 US claimed
EP-4596053-A2 HDAC INHIBITORS FOR USE WITH NK CELL BASED THERAPIES Viracta Subsidiary, Inc. (US) 2025-08-06 EP claimed
EP-3484489-B1 HDAC INHIBITORS FOR USE WITH NK CELL BASED THERAPIES VIRACTA SUBSIDIARY INC (US) 2025-06-18 EP claimed
US-20240390375-A1 METHODS AND COMPOSITIONS FOR TREATING VIRAL OR VIRALLY-INDUCED CONDITIONS Viracta Subsidiary, Inc. (US) 2024-11-28 US claimed
WO-2024192348-A2 METHODS OF TREATING HPV IN HIV-INFECTED PATIENTS OHIO STATE INNOVATION FOUNDATION (US) 2024-09-19 WO claimed
US-12083119-B2 Methods and compositions for treating viral or virally-induced conditions Viracta Subsidiary, Inc. (US) 2024-09-10 US claimed
US-20190290646-A1 HDAC INHIBITORS FOR USE WITH NK CELL BASED THERAPIES INFINITY SA LLC, AS PURCHASER AGENT 2019-09-26 US claimed
US-20190216818-A1 HISTONE DEACETYLASE INHIBITORS FOR USE IN IMMUNOTHERAPY VIRACTA THERAPEUTICS, INC. (US) 2019-07-18 US claimed
EP-3484478-A1 HISTONE DEACETYLASE INHIBITORS FOR USE IN IMMUNOTHERAPY Viracta Therapeutics, Inc. (US) 2019-05-22 EP claimed
EP-3484489-A1 HDAC INHIBITORS FOR USE WITH NK CELL BASED THERAPIES Viracta Therapeutics, Inc. (US) 2019-05-22 EP claimed
WO-2018013975-A1 HDAC INHIBITORS FOR USE WITH NK CELL BASED THERAPIES VIRACTA THERAPEUTICS, INC. (US) 2018-01-18 WO claimed
WO-2018013962-A1 HISTONE DEACETYLASE INHIBITORS FOR USE IN IMMUNOTHERAPY VIRACTA THERAPEUTICS, INC. (US) 2018-01-18 WO claimed
US-20130331313-A1 METHODS AND COMPOSITIONS FOR TREATING VIRAL OR VIRALLY-INDUCED CONDITIONS TRUSTEES OF BOSTON UNIVERSITY 2013-12-12 US claimed
US-20110245154-A1 Methods and Compositions for Treating Viral or Virally-Induced Conditions HEMAQUEST PHARMACEUTICALS, INC. (US) 2011-10-06 US claimed
WO-2011113013-A2 METHODS AND COMPOSITIONS FOR TREATING VIRAL OR VIRALLY-INDUCED CONDITIONS HEMAQUEST PHARMACEUTICALS, INC. (US) 2011-09-15 WO claimed
EP-1881977-B1 HISTONE DEACETYLASE INHIBITORS CHROMA THERAPEUTICS LTD (GB) 2011-01-05 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260007676-A1 HDAC INHIBITORS FOR USE WITH NK CELL BASED THERAPIES HDAC9, HDAC4, HDAC5 HDAC3 5/4885HDAC4 2/4885HDAC1 11/4885
US-20260000672-A1 HISTONE DEACETYLASE INHIBITORS FOR USE IN IMMUNOTHERAPY HDAC7, HDAC8, HDAC9 HDAC3 10/4885HDAC4 4/4885HDAC1 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.