Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10147542 | 0.81 | MAPK13 (0.37) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL351741 | 0.79 | CNR2 (0.47) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10146112 | 0.79 | PIK3CG (0.38) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10147503 | 0.78 | MAPT (0.37) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10147796 | 0.76 | MAPT (0.37) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13618555 | 0.76 | KDM4E (0.36) | — | |
| SCHEMBL10147583 | 0.76 | SCN10A (0.39) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10147546 | 0.73 | MAPT (0.37) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10147538 | 0.72 | MAPK14 (0.40) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10147586 | 0.70 | CNR2 (0.35) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418207-A1 | Sulfone compounds which modulate the CB2 receptor | Boehringer Ingelheim International GmbH (DE) | 2012-02-15 | — | — | EP | disclosed |