Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 16/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695360 | 1.00 | PIK3R2 (0.52) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695012 | 0.94 | PIK3R2 (0.47) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL14815987 | 0.94 | PIK3R2 (0.47) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695240 | 0.89 | PIK3CD (0.52) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL10147661 | 0.89 | PIK3CD (0.52) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL14815738 | 0.88 | PIK3CD (0.53) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL10147628 | 0.88 | PIK3CD (0.54) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL14815737 | 0.88 | PIK3CD (0.53) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695133 | 0.88 | PIK3CD (0.54) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL14815712 | 0.88 | PIK3R2 (0.46) | PIK3R2PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130085131-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130085131-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130085131-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-04 | — | — | US | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085131-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, SSB, BCL9 | PIK3R2 2603/4885PIK3CD 1181/4885PIK3CG 2150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.