Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695146 | 0.90 | PIK3CD (0.54) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL14815216 | 0.90 | PIK3CD (0.54) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL10147634 | 0.88 | PIK3CD (0.51) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL10146956 | 0.87 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL10146906 | 0.79 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL10147648 | 0.78 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695016 | 0.78 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695469 | 0.78 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL14816042 | 0.78 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL14815228 | 0.78 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |