Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11211872 | 0.86 | KDM4E (0.50) | TSHRTAAR1MAPK1LMNAGLA | |
| SCHEMBL20200250 | 0.86 | PDCD1 (0.51) | PDCD1CD274TSHRTAAR1MAPK1 | |
| SCHEMBL31280574 | 0.86 | PDCD1 (0.51) | PDCD1CD274TSHRTAAR1MAPK1 | |
| SCHEMBL13555256 | 0.86 | TAAR1 (0.67) | TSHRTAAR1MAPK1LMNAGLA | |
| SCHEMBL12088053 | 0.85 | TSHR (0.47) | TSHRTAAR1MAPK1LMNAGLA | |
| SCHEMBL16231315 | 0.83 | PDCD1 (0.49) | PDCD1CD274TSHRTAAR1MAPK1 | |
| SCHEMBL1848551 | 0.83 | TAAR1 (0.52) | TSHRTAAR1MAPK1LMNAGLA | |
| SCHEMBL31435368 | 0.83 | PDCD1 (0.49) | PDCD1CD274TSHRTAAR1MAPK1 | |
| SCHEMBL1587262 | 0.81 | PDCD1 (0.47) | PDCD1CD274TSHRTAAR1MAPK1 | |
| SCHEMBL7470025 | 0.81 | KDM4E (0.46) | TSHRTAAR1MAPK1LMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827920-B2 | Nanostructure, a biosensor including the nanostructure, and a screening method | POSTECH Research and Business Development Foundation (KR) | 2023-11-28 | — | — | US | disclosed |
| WO-2023201282-A1 | NOVEL GSPT1 COMPOUNDS AND METHODS OF USE OF THE NOVEL COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-10-19 | — | — | WO | disclosed |
| US-9040706-B2 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-8980837-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8907092-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8835393-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-20120270886-A1 | INHIBITORS OF IAP | KOEHLER MICHAEL F T (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120202750-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20110269696-A1 | INHIBITORS OF IAPS | GENENTECH INC. (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110218211-A1 | AZAINDOLE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-20110077265-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2011-03-31 | — | — | US | disclosed |
| US-20110046066-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269696-A1 | INHIBITORS OF IAPS | XIAP, BIRC5, BIRC3 | PDCD1 692/4885CD274 2316/4885TSHR 3661/4885 |
| US-20110046066-A1 | INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | PDCD1 982/4885CD274 2031/4885TSHR 2216/4885 |
| US-20120202750-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC3 | PDCD1 1112/4885CD274 2167/4885TSHR 2845/4885 |
| US-20120270886-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC3 | PDCD1 1635/4885CD274 2592/4885TSHR 3278/4885 |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | PDCD1 817/4885CD274 2444/4885TSHR 3064/4885 |
| US-20110218211-A1 | AZAINDOLE INHIBITORS OF IAP | XIAP, BIRC5, API5 | PDCD1 1281/4885CD274 2280/4885TSHR 3045/4885 |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC2 | PDCD1 276/4885CD274 1543/4885TSHR 3205/4885 |
| US-20110077265-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC2 | PDCD1 1593/4885CD274 2835/4885TSHR 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.