Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | AIP | O00170 | 1/20 | 0.31 |
| ▸ | SGTA | O43765 | 1/20 | 0.31 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.31 |
| ▸ | STIP1 | P31948 | 1/20 | 0.31 |
| ▸ | PPP5C | P53041 | 1/20 | 0.31 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349083 | 0.92 | POLB (0.44) | POLBALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL13948530 | 0.84 | POLB (0.46) | POLBALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL1003996 | 0.81 | POLB (0.52) | POLBALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL2221293 | 0.81 | POLB (0.52) | POLBALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL7406703 | 0.78 | POLB (0.50) | POLBALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL1004648 | 0.78 | POLB (0.55) | POLBALDH1A1KMT2AMEN1HSD17B10 | |
| Hydrochloric Acid SCHEMBL29030889 | 0.75 | POLB (0.52) | POLBALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL13961523 | 0.75 | POLB (0.38) | POLBALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL12257171 | 0.72 | KDM4E (0.41) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL2221290 | 0.72 | POLB (0.44) | POLBALDH1A1KMT2AMEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046303-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2012-02-23 | — | — | US | disclosed |
| US-8067613-B2 | Benzimidazole poly(ADP ribose)polymerase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | POLB 21/4885ALDH1A1 769/4885KMT2A 1776/4885 |
| US-20120046303-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | POLB 21/4885ALDH1A1 769/4885KMT2A 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.