Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 13/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.33 |
| ▸ | PLK4 | O00444 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10150208 | 0.89 | HSP90AB1 (0.48) | HSP90AB1MAOAMKNK2MAOBCCNA2 | |
| SCHEMBL10150206 | 0.83 | HSP90AB1 (0.44) | HSP90AB1MAOAMKNK2MAOBMKNK1 | |
| SCHEMBL10150178 | 0.81 | HSP90AB1 (0.71) | HSP90AB1MAOAMKNK2CCNA2CDK2 | |
| SCHEMBL10150157 | 0.81 | HSP90AB1 (0.71) | HSP90AB1MAOAMKNK2CCNA2CDK2 | |
| SCHEMBL10150204 | 0.80 | MKNK2 (0.45) | HSP90AB1MAOAMKNK2MAOBCCNA2 | |
| SCHEMBL10150190 | 0.78 | HSP90AB1 (0.54) | HSP90AB1MAOAMKNK2MAOBCCNA2 | |
| SCHEMBL10150201 | 0.77 | HSP90AB1 (0.48) | HSP90AB1MAOAMKNK2FLT3MKNK1 | |
| SCHEMBL14155862 | 0.76 | MKNK2 (0.41) | HSP90AB1MAOAMKNK2FLT3MKNK1 | |
| SCHEMBL10150687 | 0.75 | HSP90AB1 (0.41) | HSP90AB1MAOAMKNK2POLL | |
| SCHEMBL10150088 | 0.73 | HSP90AB1 (0.68) | HSP90AB1MAOAMKNK2MAOBCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450305-B2 | Macrocyclic compounds useful as inhibitors of kinases and HSP90 | UNIVERSITE DE STRASBOURG (FR) | 2013-05-28 | — | — | US | disclosed |
| US-20120077775-A1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077775-A1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AB1 1/4885MAOA 3967/4885MKNK2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.