Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F13A1 | P00488 | 1/20 | 0.60 |
| ▸ | TGM2 | P21980 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GEMIN4 | P57678 | 1/20 | 0.42 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10150871 | 1.00 | F13A1 (0.60) | F13A1TGM2MAPTGEMIN4HSF1 | |
| SCHEMBL10150148 | 0.87 | F13A1 (0.59) | F13A1TGM2MAPTGEMIN4HSF1 | |
| SCHEMBL10150149 | 0.87 | F13A1 (0.59) | F13A1TGM2MAPTGEMIN4HSF1 | |
| SCHEMBL10150851 | 0.87 | F13A1 (0.59) | F13A1TGM2MAPTGEMIN4HSF1 | |
| SCHEMBL10150866 | 0.86 | F13A1 (0.72) | F13A1TGM2MAPTGEMIN4HSF1 | |
| SCHEMBL10150862 | 0.86 | F13A1 (0.72) | F13A1TGM2MAPTGEMIN4HSF1 | |
| SCHEMBL13983849 | 0.85 | F13A1 (0.67) | F13A1TGM2MAPTGEMIN4HSF1 | |
| SCHEMBL10150861 | 0.84 | HSP90AB1 (0.61) | F13A1TGM2MAPTRAB9ANPSR1 | |
| SCHEMBL10150028 | 0.83 | F13A1 (0.61) | F13A1TGM2MAPTGEMIN4HSF1 | |
| SCHEMBL10150860 | 0.82 | F13A1 (0.58) | F13A1TGM2MAPTGEMIN4HSF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077775-A1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077775-A1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | HSP90AB1, HSP90AA1, HSP90AB2P | F13A1 3067/4885TGM2 3060/4885MAPT 1982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.