Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.49 |
| ▸ | F13A1 | P00488 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 6/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 4/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.40 |
| ▸ | FLT4 | P35916 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10150262 | 0.93 | MKNK2 (0.51) | MKNK2F13A1TGM2HSP90AB1MKNK1 | |
| SCHEMBL10150278 | 0.89 | MKNK2 (0.46) | MKNK2F13A1TGM2HSP90AB1MKNK1 | |
| SCHEMBL10150879 | 0.88 | MKNK2 (0.38) | MKNK2F13A1TGM2HSP90AB1MKNK1 | |
| SCHEMBL10150265 | 0.84 | MKNK2 (0.57) | MKNK2F13A1TGM2HSP90AB1MKNK1 | |
| SCHEMBL14293556 | 0.84 | MKNK2 (0.51) | MKNK2F13A1TGM2HSP90AB1MKNK1 | |
| SCHEMBL10150272 | 0.84 | MKNK2 (0.51) | MKNK2F13A1TGM2HSP90AB1MKNK1 | |
| SCHEMBL10150219 | 0.83 | MKNK2 (0.50) | MKNK2F13A1TGM2HSP90AB1MKNK1 | |
| SCHEMBL10150274 | 0.83 | MKNK2 (0.50) | MKNK2F13A1TGM2HSP90AB1MKNK1 | |
| SCHEMBL10150310 | 0.83 | F13A1 (0.40) | MKNK2F13A1TGM2HSP90AB1MKNK1 | |
| SCHEMBL10150320 | 0.82 | F13A1 (0.39) | MKNK2F13A1TGM2HSP90AB1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077775-A1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077775-A1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | HSP90AB1, HSP90AA1, HSP90AB2P | MKNK2 12/4885F13A1 3067/4885TGM2 3060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.