Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.39 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019254 | 0.81 | TSHR (0.47) | ARMRGPRX4TSHRTTRSMN1; SMN2 | |
| SCHEMBL13452529 | 0.77 | MRGPRX4 (0.70) | ARMRGPRX4TSHRTTRNPC1 | |
| SCHEMBL1015554 | 0.75 | KDM4E (0.38) | ADRB1ADRB3RAB9AKDM4EALDH1A1 | |
| SCHEMBL1253721 | 0.73 | KDM4E (0.39) | ARTSHRADRB1ADRB3TTR | |
| SCHEMBL1020851 | 0.73 | KDM4E (0.39) | ARTSHRADRB1ADRB3TTR | |
| SCHEMBL1020850 | 0.73 | KDM4E (0.39) | ARTSHRADRB1ADRB3TTR | |
| SCHEMBL1016641 | 0.72 | TSHR (0.42) | TSHRADRB1ADRB3TTRRAB9A | |
| SCHEMBL1018604 | 0.72 | TSHR (0.42) | TSHRADRB1ADRB3TTRRAB9A | |
| SCHEMBL1016642 | 0.72 | TSHR (0.42) | TSHRADRB1ADRB3TTRRAB9A | |
| SCHEMBL21899848 | 0.71 | TSHR (0.63) | ARMRGPRX4TSHRTTRSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271642-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009126863-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-10-15 | — | — | WO | disclosed |