Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.58 |
| ▸ | KDM6A | O15550 | 3/20 | 0.57 |
| ▸ | KDM5C | P41229 | 3/20 | 0.57 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.57 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.57 |
| ▸ | KDM6B | O15054 | 2/20 | 0.57 |
| ▸ | KDM4A | O75164 | 2/20 | 0.57 |
| ▸ | KDM4B | O94953 | 2/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.57 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.57 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.57 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.57 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722008 | 0.92 | HDAC1 (0.61) | HDAC1KDM6AKDM5CKDM5BKDM2B | |
| SCHEMBL10158454 | 0.88 | KDM6A (0.65) | HDAC1KDM6AKDM5CKDM5BKDM2B | |
| SCHEMBL10157696 | 0.82 | KDM6A (0.60) | HDAC1KDM6AKDM5CKDM5BKDM2B | |
| SCHEMBL2721826 | 0.80 | KDM6A (0.67) | HDAC1KDM6AKDM5CKDM5BKDM2B | |
| SCHEMBL10157727 | 0.80 | KDM6A (0.67) | HDAC1KDM6AKDM5CKDM5BKDM2B | |
| SCHEMBL14931841 | 0.79 | KDM6A (0.66) | HDAC1KDM6AKDM5CKDM5BKDM2B | |
| SCHEMBL14931745 | 0.78 | KDM6A (0.64) | HDAC1KDM6AKDM5CKDM5BKDM2B | |
| SCHEMBL2723353 | 0.78 | KDM6A (0.64) | HDAC1KDM6AKDM5CKDM5BKDM2B | |
| SCHEMBL10156418 | 0.78 | KDM6A (0.64) | HDAC1KDM6AKDM5CKDM5BKDM2B | |
| SCHEMBL29409239 | 0.78 | HDAC1 (0.66) | HDAC1KDM6AKDM5CKDM5BKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052390-A1 | N-2-(2-PYRIDINYL)-4-PYRIMIDINYL-BETA-ALANINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE JMJD3 | GLAXO GROUP LIMITED (GB) | 2012-04-26 | — | — | WO | disclosed |