Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.75 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.75 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10157899 | 0.90 | MTOR (0.74) | MTORPIK3CA | |
| SCHEMBL10158167 | 0.89 | MTOR (0.75) | MTORPIK3CA | |
| SCHEMBL10158161 | 0.89 | MTOR (0.75) | MTORPIK3CA | |
| SCHEMBL6892291 | 0.86 | MTOR (1.00) | MTORPIK3CA | |
| SCHEMBL12774568 | 0.85 | MTOR (0.74) | MTORPIK3CA | |
| SCHEMBL10158603 | 0.84 | MTOR (0.73) | MTORPIK3CAATR | |
| SCHEMBL12137786 | 0.82 | MTOR (0.57) | MTORPIK3CA | |
| SCHEMBL10157640 | 0.82 | MTOR (0.75) | MTORPIK3CA | |
| SCHEMBL12138002 | 0.80 | MTOR (0.63) | MTORPIK3CA | |
| SCHEMBL12137824 | 0.79 | MTOR (0.53) | MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028952-A1 | 5-ALKYNYL-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028952-A1 | 5-ALKYNYL-PYRIMIDINES | MKI67, CCNA1, CCNT1 | MTOR 1291/4885PIK3CA 1371/4885ATR 507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.