SCHEMBL10159314 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	KDM5A	P29375	3/20	0.49

▸	POLB	P06746	1/20	0.47

▸	EPHX2	P34913	11/20	0.45

▸	EPHX1	P07099	4/20	0.45

▸	MTNR1A	P48039	2/20	0.40

▸	MTNR1B	P49286	2/20	0.40

▸	KDM5C	P41229	1/20	0.39

▸	KDM5B	Q9UGL1	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10155587	0.90	KDM5A (0.47)	KDM5APOLBEPHX2EPHX1KDM5C
SCHEMBL13853820	0.86	CA1 (0.50)	KDM5APOLBEPHX2EPHX1
SCHEMBL13853798	0.86	CA1 (0.50)	KDM5APOLBEPHX2EPHX1
SCHEMBL13853840	0.85	KDM5A (0.52)	KDM5APOLBEPHX2EPHX1KDM5C
SCHEMBL10159306	0.84	MAPK1 (0.51)	KDM5APOLBEPHX2EPHX1KDM5C
SCHEMBL13853811	0.83	KDM5A (0.47)	KDM5APOLBEPHX2EPHX1
SCHEMBL13853825	0.83	KDM5A (0.47)	KDM5APOLBEPHX2EPHX1
SCHEMBL13853823	0.83	HTT (0.56)	POLBKDM5B
SCHEMBL13853847	0.83	KDM5A (0.51)	KDM5AKDM5CKDM5B
SCHEMBL13853804	0.83	HTT (0.56)	POLBKDM5B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8193164-B2	Organic compounds	NOVARTIS AG (CH)	2012-06-05	—	—	US	disclosed
US-8193164-B2	Organic compounds	NOVARTIS AG (CH)	2012-06-05	—	—	US	disclosed