Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 3/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.40 |
| ▸ | AKT1 | P31749 | 6/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | STK4 | Q13043 | 1/20 | 0.34 |
| ▸ | STK3 | Q13188 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10158964 | 0.93 | AKT2 (0.43) | AKT2GSK3BFPR2PROKR1RPS6KB1 | |
| SCHEMBL473333 | 0.89 | RPS6KB1 (0.48) | AKT2GSK3BFPR2PROKR1RPS6KB1 | |
| SCHEMBL473338 | 0.87 | RPS6KB1 (0.53) | AKT2GSK3BFPR2PROKR1RPS6KB1 | |
| SCHEMBL29894639 | 0.87 | RPS6KB1 (0.53) | AKT2GSK3BFPR2PROKR1RPS6KB1 | |
| SCHEMBL473379 | 0.87 | RPS6KB1 (0.53) | AKT2GSK3BFPR2PROKR1RPS6KB1 | |
| SCHEMBL473380 | 0.87 | RPS6KB1 (0.53) | AKT2GSK3BFPR2PROKR1RPS6KB1 | |
| SCHEMBL473369 | 0.86 | RPS6KB1 (0.45) | AKT2GSK3BFPR2PROKR1RPS6KB1 | |
| SCHEMBL473372 | 0.86 | RPS6KB1 (0.45) | AKT2GSK3BFPR2PROKR1RPS6KB1 | |
| SCHEMBL473347 | 0.85 | RPS6KB1 (0.53) | AKT2GSK3BFPR2PROKR1RPS6KB1 | |
| SCHEMBL473348 | 0.85 | RPS6KB1 (0.53) | AKT2GSK3BFPR2PROKR1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848719-B1 | [1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YL]-PIPERIDINE OR -PIPERAZINE COMPOUNDS AS SERINE-THREONINE KINASE MODULATORS (P70S6K, ATK1 AND ATK2) FOR THE TREATMENT OF IMMUNOLOGICAL, INFLAMMATORY AND PROLIFERATIVE DISEASES | EXELIXIS INC (US) | 2012-02-01 | — | — | EP | disclosed |