Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016149 | 1.00 | EGFR (0.65) | EGFRERBB2PDGFRBKITSRC | |
| SCHEMBL1016944 | 0.99 | EGFR (0.66) | EGFRERBB2PDGFRBKITSRC | |
| SCHEMBL1016942 | 0.99 | EGFR (0.66) | EGFRERBB2PDGFRBKITSRC | |
| SCHEMBL1016842 | 0.93 | EGFR (0.71) | EGFRERBB2MKNK1 | |
| SCHEMBL1016841 | 0.93 | EGFR (0.71) | EGFRERBB2MKNK1 | |
| SCHEMBL18355001 | 0.91 | EGFR (0.62) | EGFRMKNK1 | |
| SCHEMBL12955496 | 0.90 | EGFR (0.66) | EGFRMKNK1 | |
| SCHEMBL12955268 | 0.90 | EGFR (0.75) | EGFRMKNK1 | |
| SCHEMBL1016402 | 0.89 | EGFR (0.62) | EGFRERBB2MKNK1 | |
| SCHEMBL1016403 | 0.89 | EGFR (0.62) | EGFRERBB2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001890-B1 | TETRAHYDROPYRIDOTHIENOPYRIMIDINE COMPOUNDS AND USE FOR THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | BAYER SCHERING PHARMA AG (DE) | 2011-01-12 | — | — | EP | disclosed |