Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016242 | 1.00 | EGFR (0.57) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL938737 | 0.94 | EGFR (0.66) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL938735 | 0.94 | EGFR (0.66) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1015980 | 0.94 | EGFR (0.62) | EGFRERBB2ERBB4 | |
| SCHEMBL1015981 | 0.94 | EGFR (0.62) | EGFRERBB2ERBB4 | |
| SCHEMBL1016915 | 0.92 | EGFR (0.60) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1016917 | 0.92 | EGFR (0.60) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1017062 | 0.89 | EGFR (0.57) | EGFR | |
| SCHEMBL1015944 | 0.89 | EGFR (0.61) | EGFRERBB2 | |
| SCHEMBL1015945 | 0.89 | EGFR (0.61) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001890-B1 | TETRAHYDROPYRIDOTHIENOPYRIMIDINE COMPOUNDS AND USE FOR THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | BAYER SCHERING PHARMA AG (DE) | 2011-01-12 | — | — | EP | disclosed |