Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.80 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | RAF1 | P04049 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | YES1 | P07947 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.64 |
| ▸ | TEK | Q02763 | 1/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3497104 | 1.00 | BRAF (0.80) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL3496951 | 0.94 | BRAF (0.70) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1013858 | 0.94 | BRAF (0.70) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1016721 | 0.92 | BRAF (0.80) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL3497516 | 0.91 | BRAF (0.67) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1019435 | 0.90 | BRAF (0.75) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1019434 | 0.90 | BRAF (0.75) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1020083 | 0.90 | BRAF (0.80) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1016011 | 0.89 | BRAF (1.00) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1016749 | 0.86 | BRAF (0.77) | BRAFABL1EGFRRAF1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271649-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | Wyeth LLC (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009108838-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |