Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 14/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10163038 | 0.87 | EPAS1 (0.42) | PTGDR2EPAS1 | |
| SCHEMBL1650643 | 0.84 | PTGDR2 (0.46) | PTGDR2EPAS1PTGDR | |
| SCHEMBL2065952 | 0.81 | PTGDR2 (0.55) | PTGDR2EPAS1PTGDR | |
| SCHEMBL585797 | 0.79 | PTGDR2 (0.45) | PTGDR2EPAS1PTGDR | |
| SCHEMBL586217 | 0.77 | PTGDR2 (0.44) | PTGDR2EPAS1PTGDR | |
| SCHEMBL585344 | 0.75 | PTGDR2 (0.42) | PTGDR2EPAS1PTGDR | |
| SCHEMBL1651360 | 0.75 | EPAS1 (0.49) | PTGDR2EPAS1 | |
| SCHEMBL14490991 | 0.75 | EPAS1 (0.47) | PTGDR2EPAS1PTGDR | |
| SCHEMBL1652886 | 0.75 | EPAS1 (0.45) | PTGDR2EPAS1 | |
| SCHEMBL4792091 | 0.73 | PTGDR2 (0.43) | PTGDR2EPAS1PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963259-B1 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2012-02-15 | — | — | EP | disclosed |