Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.54 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.54 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357282 | 0.92 | PIK3CD (0.63) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL356154 | 0.92 | PIK3CD (0.63) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL30230513 | 0.92 | PIK3CD (0.63) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL357616 | 0.90 | PIK3CD (0.77) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL356740 | 0.90 | PIK3CD (0.77) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL355226 | 0.89 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL358082 | 0.87 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL356449 | 0.85 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL29422878 | 0.85 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB | |
| SCHEMBL356503 | 0.85 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160075705-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2016-03-17 | — | — | US | disclosed |
| US-9149477-B2 | 5-fluoro-3-phenyl-2-[1-(9h-purin-6-ylamino)propyl]-3h-quinazolin-4-one as an inhibitor of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2015-10-06 | — | — | US | disclosed |
| US-8993583-B2 | 5-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)propyl]-3H-quinazolin-4-one and 6-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)ethyl]-3H-quinazolin-4-one as inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2015-03-31 | — | — | US | disclosed |
| US-8980901-B2 | 5-fluoro-3-phenyl-2[1-(9H-purin-6-ylamino)propyl]-3H-quinazolin-4-one and 6-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)ethyl]-3H-quinazolin-4-one as inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140378479-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2014-12-25 | — | — | US | disclosed |
| US-8779131-B2 | 6-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)-ethyl]-3H-quinazolin-4-one as an inhibitor of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2014-07-15 | — | — | US | disclosed |
| US-20140121223-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2014-05-01 | — | — | US | disclosed |
| US-20140121224-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2014-05-01 | — | — | US | disclosed |
| US-8586597-B2 | 6-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)ethyl]-3H-quinazolin-4-one as an inhibitor of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2013-11-19 | — | — | US | disclosed |
| US-RE44599-E1 | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2013-11-12 | — | — | US | disclosed |
| US-20130231356-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130116266-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2013-05-09 | — | — | US | disclosed |
| US-8207153-B2 | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-06-26 | — | — | US | disclosed |
| US-20120015964-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2012-01-19 | — | — | US | disclosed |
| US-7932260-B2 | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2011-04-26 | — | — | US | disclosed |
| US-20100256168-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2010-10-07 | — | — | US | disclosed |
| US-20100256167-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140121224-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYOSITOL 3-KINASE DELTA | PIK3CD, PIK3CB, PIK3CG | PIK3CD 1/4885PIK3CG 3/4885PIK3R1 25/4885 |
| US-20100256167-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PI4KA | PIK3CD 1/4885PIK3CG 4/4885PIK3R1 12/4885 |
| US-20140121223-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PI4KA | PIK3CD 1/4885PIK3CG 4/4885PIK3R1 12/4885 |
| US-20120015964-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PI4KA | PIK3CD 1/4885PIK3CG 4/4885PIK3R1 12/4885 |
| US-20100256168-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PI4KA | PIK3CD 1/4885PIK3CG 4/4885PIK3R1 12/4885 |
| US-20140378479-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PI4KA | PIK3CD 1/4885PIK3CG 4/4885PIK3R1 12/4885 |
| US-20130116266-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PI4KA, PI4KB, PIK3CD | PIK3CD 3/4885PIK3CG 16/4885PIK3R1 86/4885 |
| US-20130231356-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PI4KA | PIK3CD 1/4885PIK3CG 4/4885PIK3R1 12/4885 |
| US-20160075705-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PI4KA | PIK3CD 1/4885PIK3CG 4/4885PIK3R1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.