Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.81 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | RAF1 | P04049 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | YES1 | P07947 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.65 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.65 |
| ▸ | TEK | Q02763 | 1/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015905 | 0.94 | BRAF (0.79) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1015694 | 0.90 | BRAF (0.80) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL3495782 | 0.90 | BRAF (1.00) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL13499897 | 0.87 | BRAF (0.74) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1014031 | 0.86 | BRAF (0.78) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1013970 | 0.86 | BRAF (1.00) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1016687 | 0.86 | BRAF (0.80) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL1013595 | 0.85 | BRAF (0.68) | BRAFABL1EGFRRAF1LCK | |
| Hydrochloric Acid SCHEMBL1019058 | 0.85 | BRAF (0.79) | BRAFABL1EGFRRAF1LCK | |
| SCHEMBL3497530 | 0.85 | BRAF (0.68) | BRAFABL1EGFRRAF1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271649-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | Wyeth LLC (US) | 2011-01-12 | — | — | EP | claimed |
| WO-2009108838-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | claimed |
| EP-2271649-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | Wyeth LLC (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009108838-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |