Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.59 |
| ▸ | JAK3 | P52333 | 2/20 | 0.59 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016470 | 1.00 | EGFR (0.72) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL3617894 | 0.99 | EGFR (0.72) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1017359 | 0.94 | EGFR (0.72) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1016877 | 0.94 | EGFR (0.72) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1017361 | 0.94 | EGFR (0.72) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1016878 | 0.94 | EGFR (0.72) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1015363 | 0.90 | EGFR (0.63) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1015364 | 0.90 | EGFR (0.63) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1014112 | 0.89 | EGFR (0.89) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1014111 | 0.89 | EGFR (0.89) | EGFRERBB2JAK3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001890-B1 | TETRAHYDROPYRIDOTHIENOPYRIMIDINE COMPOUNDS AND USE FOR THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | BAYER SCHERING PHARMA AG (DE) | 2011-01-12 | — | — | EP | disclosed |