Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2632476 | 0.87 | POLB (0.40) | EZH2DAOATMNR4A2POLB | |
| SCHEMBL2632475 | 0.72 | POLB (0.43) | DAOPOLBKDM4EGAA | |
| SCHEMBL1655471 | 0.68 | ATM (0.45) | DAOATMPOLBSMN1; SMN2LMNA | |
| SCHEMBL2632474 | 0.68 | POLB (0.41) | DAOPOLBKMT2A | |
| SCHEMBL16344549 | 0.67 | EZH2 (0.53) | EZH2ATMNR4A2LMNAALDH1A1 | |
| SCHEMBL2632366 | 0.65 | POLB (0.48) | DAONR4A2POLBLMNAALDH1A1 | |
| SCHEMBL2632481 | 0.65 | NR4A2 (0.43) | NR4A2POLBLMNAALDH1A1KMT2A | |
| SCHEMBL24165535 | 0.64 | KDM4E (0.43) | NR4A2ALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL10362653 | 0.64 | CYP2C9 (0.40) | SMN1; SMN2LMNAALDH1A1KDM4EHTT | |
| SCHEMBL1654671 | 0.62 | CLEC4M (0.48) | DAOPOLBSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054874-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-04-26 | — | — | WO | disclosed |