Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.67 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.60 |
| ▸ | GSK3B | P49841 | 4/20 | 0.60 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.60 |
| ▸ | PRKD2 | Q9BZL6 | 4/20 | 0.60 |
| ▸ | CSNK1G1 | Q9HCP0 | 4/20 | 0.60 |
| ▸ | CSNK1G3 | Q9Y6M4 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | GSK3A | P49840 | 3/20 | 0.60 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.60 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.60 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2745352 | 1.00 | BRAF (0.67) | BRAFMAPK8MAPK9PRKD3MAP4K4 | |
| SCHEMBL2745216 | 0.94 | BRAF (0.74) | BRAFMAPK8MAPK9PRKD3MAP4K4 | |
| SCHEMBL2746280 | 0.94 | BRAF (0.74) | BRAFMAPK8MAPK9PRKD3MAP4K4 | |
| SCHEMBL3477985 | 0.92 | MAPK8 (0.66) | BRAFMAPK8MAPK9PRKD3MAP4K4 | |
| SCHEMBL2745867 | 0.91 | BRAF (0.70) | BRAFMAPK8MAPK9PRKD3MAP4K4 | |
| SCHEMBL2745281 | 0.91 | BRAF (0.70) | BRAFMAPK8MAPK9PRKD3MAP4K4 | |
| SCHEMBL2745810 | 0.91 | BRAF (0.69) | BRAFMAPK8MAPK9PRKD3MAP4K4 | |
| SCHEMBL3478582 | 0.90 | BRAF (0.68) | BRAFMAPK8MAPK9PRKD3MAP4K4 | |
| SCHEMBL2745225 | 0.89 | BRAF (0.69) | BRAFMAPK8MAPK9PRKD3MAP4K4 | |
| SCHEMBL2746086 | 0.89 | BRAF (0.67) | BRAFMAPK8MAPK9PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178672-B2 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase | ARQULE, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-8178672-B2 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase | ARQULE, INC. (US) | 2012-05-15 | — | — | US | disclosed |