Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.57 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | UBE2I | P63279 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10166441 | 0.90 | HCRTR2 (0.58) | HCRTR2HCRTR1TP53THRBHDAC1 | |
| SCHEMBL10166866 | 0.89 | HCRTR2 (0.58) | HCRTR2HCRTR1TP53HDAC1ACHE | |
| SCHEMBL10166451 | 0.89 | TP53 (0.51) | HCRTR2HCRTR1TP53ALDH1A1HDAC1 | |
| SCHEMBL666604 | 0.83 | HCRTR2 (0.40) | HCRTR2HCRTR1POLBDYRK1AGSK3B | |
| SCHEMBL10165791 | 0.83 | TP53 (0.51) | HCRTR2TP53THRBHDAC1ACHE | |
| SCHEMBL667539 | 0.81 | HCRTR2 (0.78) | HCRTR2HCRTR1TP53KDM4EPOLB | |
| SCHEMBL667759 | 0.81 | HCRTR2 (0.80) | HCRTR2HCRTR1TP53KDM4EPOLB | |
| SCHEMBL667564 | 0.76 | HCRTR2 (0.89) | HCRTR2HCRTR1TP53KDM4EALDH1A1 | |
| SCHEMBL667753 | 0.73 | HCRTR2 (0.41) | HCRTR2HCRTR1DYRK1AGSK3B | |
| SCHEMBL667875 | 0.73 | HCRTR2 (1.00) | HCRTR2HCRTR1TP53KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046289-A1 | Pyridazine Carboxamide Orexin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046289-A1 | Pyridazine Carboxamide Orexin Receptor Antagonists | HCRTR2, HCRTR1, NPY5R | HCRTR2 1/4885HCRTR1 2/4885TP53 4884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.