Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016711 | 1.00 | EGFR (0.67) | EGFRMKNK1ERBB2 | |
| SCHEMBL1017039 | 0.95 | EGFR (0.68) | EGFRMKNK1ERBB2 | |
| SCHEMBL1017041 | 0.95 | EGFR (0.68) | EGFRMKNK1ERBB2 | |
| SCHEMBL3616602 | 0.94 | EGFR (0.70) | EGFRMKNK1ERBB2 | |
| SCHEMBL1017735 | 0.93 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL1017734 | 0.93 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL1015556 | 0.92 | EGFR (0.80) | EGFRMKNK1ERBB2 | |
| SCHEMBL1016383 | 0.92 | EGFR (0.68) | EGFRMKNK1ERBB2 | |
| SCHEMBL1016382 | 0.92 | EGFR (0.68) | EGFRMKNK1ERBB2 | |
| SCHEMBL1015558 | 0.92 | EGFR (0.80) | EGFRMKNK1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001890-B1 | TETRAHYDROPYRIDOTHIENOPYRIMIDINE COMPOUNDS AND USE FOR THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | BAYER SCHERING PHARMA AG (DE) | 2011-01-12 | — | — | EP | disclosed |