Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1053096 | 1.00 | TSHR (0.63) | TSHRTDP1ALDH1A1LMNACNR1 | |
| SCHEMBL18638430 | 1.00 | TSHR (0.63) | TSHRTDP1ALDH1A1LMNACNR1 | |
| SCHEMBL9968737 | 0.88 | TSHR (0.57) | TSHRTDP1ALDH1A1LMNA | |
| SCHEMBL33385 | 0.88 | TSHR (0.57) | TSHRTDP1ALDH1A1LMNA | |
| SCHEMBL1657135 | 0.88 | TSHR (0.57) | TSHRTDP1ALDH1A1LMNAKDM4E | |
| SCHEMBL14113732 | 0.87 | TSHR (0.69) | TSHRTDP1ALDH1A1LMNATRPA1 | |
| SCHEMBL168774 | 0.87 | TSHR (0.69) | TSHRTDP1ALDH1A1LMNATRPA1 | |
| SCHEMBL6157463 | 0.86 | TSHR (0.55) | TSHRTDP1ALDH1A1LMNAKDM4E | |
| SCHEMBL6518338 | 0.86 | TSHR (0.55) | TSHRTDP1ALDH1A1LMNA | |
| SCHEMBL3365945 | 0.86 | TSHR (0.55) | TSHRTDP1ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534680-B1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PHARMACO INVESTMENTS INC (US) | 2012-02-22 | — | — | EP | disclosed |