Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.82 |
| ▸ | JAK3 | P52333 | 9/20 | 0.82 |
| ▸ | JAK2 | O60674 | 7/20 | 0.82 |
| ▸ | SYK | P43405 | 6/20 | 0.82 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.82 |
| ▸ | TYK2 | P29597 | 3/20 | 0.82 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.82 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.82 |
| ▸ | PLK4 | O00444 | 2/20 | 0.82 |
| ▸ | AURKA | O14965 | 2/20 | 0.82 |
| ▸ | STK16 | O75716 | 2/20 | 0.82 |
| ▸ | RET | P07949 | 2/20 | 0.82 |
| ▸ | FLT3 | P36888 | 2/20 | 0.82 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.82 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.82 |
| ▸ | MST1R | Q04912 | 2/20 | 0.82 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.82 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.82 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.82 |
| ▸ | ADCK1 | Q86TW2 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| R-406 SCHEMBL1200144 | 0.90 | SYK (1.00) | JAK1JAK3JAK2SYKPTK2 | |
| R-406 SCHEMBL29358236 | 0.90 | SYK (1.00) | JAK1JAK3JAK2SYKPTK2 | |
| SCHEMBL2627469 | 0.89 | SYK (0.91) | JAK1JAK3JAK2SYKPTK2 | |
| R-406 SCHEMBL12903997 | 0.87 | SYK (0.92) | JAK1JAK3JAK2SYKPTK2 | |
| SCHEMBL16606925 | 0.86 | SYK (0.81) | JAK1JAK3JAK2SYKPTK2 | |
| R-406 SCHEMBL12903982 | 0.86 | SYK (0.91) | JAK1JAK3JAK2SYKPTK2 | |
| R-406 SCHEMBL12904025 | 0.85 | SYK (0.84) | JAK1JAK3JAK2SYKPTK2 | |
| SCHEMBL11937326 | 0.85 | SYK (0.87) | JAK1JAK3JAK2SYKPTK2 | |
| R-406 SCHEMBL12904000 | 0.85 | SYK (0.89) | JAK1JAK3JAK2SYKPTK2 | |
| SCHEMBL1383686 | 0.85 | SYK (0.89) | JAK1JAK3JAK2SYKPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420505-A1 | Prodrug salts of 2, 4- pyrimidinediamine compounds and their uses | Rigel Pharmaceuticals, Inc. (US) | 2012-02-22 | — | — | EP | disclosed |