Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3495401 | 0.85 | BRAF (0.67) | BRAF | |
| SCHEMBL1013524 | 0.85 | BRAF (0.73) | BRAF | |
| SCHEMBL1017703 | 0.82 | BRAF (0.65) | BRAF | |
| SCHEMBL1013965 | 0.81 | BRAF (0.79) | BRAF | |
| SCHEMBL1014015 | 0.80 | BRAF (0.82) | BRAF | |
| SCHEMBL1016211 | 0.79 | BRAF (0.70) | BRAF | |
| SCHEMBL1013952 | 0.79 | BRAF (1.00) | BRAF | |
| SCHEMBL1015984 | 0.79 | BRAF (1.00) | BRAF | |
| SCHEMBL1019103 | 0.79 | BRAF (0.75) | BRAF | |
| SCHEMBL1014644 | 0.78 | BRAF (0.77) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271649-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | Wyeth LLC (US) | 2011-01-12 | — | — | EP | claimed |
| EP-2271649-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | Wyeth LLC (US) | 2011-01-12 | — | — | EP | disclosed |