Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 13/20 | 0.70 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12941433 | 0.92 | MAPKAPK5 (0.82) | MAPKAPK5FYNBTKKCNH2 | |
| SCHEMBL10169148 | 0.90 | MAPKAPK5 (0.87) | MAPKAPK5FYNSYK | |
| SCHEMBL1674137 | 0.89 | MAPKAPK5 (0.65) | MAPKAPK5FYN | |
| SCHEMBL10169151 | 0.89 | MAPKAPK5 (0.68) | MAPKAPK5FYNSYK | |
| SCHEMBL10169145 | 0.86 | MAPKAPK5 (0.70) | MAPKAPK5FYNBTKKCNH2SYK | |
| SCHEMBL10169134 | 0.86 | MAPKAPK5 (0.67) | MAPKAPK5BTKKCNH2SYKJAK2 | |
| SCHEMBL12443291 | 0.84 | MAPKAPK5 (0.52) | MAPKAPK5BTKKCNH2SYKJAK2 | |
| SCHEMBL10169114 | 0.84 | MAPKAPK5 (0.70) | MAPKAPK5FYNBTKKCNH2SYK | |
| SCHEMBL2068760 | 0.82 | MAPKAPK5 (1.00) | MAPKAPK5FYNSYK | |
| SCHEMBL14387664 | 0.81 | MAPKAPK5 (0.81) | MAPKAPK5FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178530-B2 | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-15 | — | — | US | disclosed |
| US-20110092497-A1 | IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA NV | 2011-04-21 | — | — | US | disclosed |
| US-7893058-B2 | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092497-A1 | IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | IKZF3, IRAK2, IRAK1 | MAPKAPK5 13/4885FYN 1514/4885BTK 3325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.