⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016517 | 0.83 | — | — | |
| SCHEMBL1019510 | 0.81 | — | — | |
| SCHEMBL2118126 | 0.79 | — | — | |
| SCHEMBL1015690 | 0.76 | — | — | |
| SCHEMBL1017295 | 0.76 | — | — | |
| SCHEMBL24149 | 0.75 | — | — | |
| SCHEMBL20523377 | 0.75 | — | — | |
| SCHEMBL8960625 | 0.74 | — | — | |
| SCHEMBL2801980 | 0.73 | — | — | |
| SCHEMBL10760444 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109422749-B | Pyrimidinedione derivative for inhibiting monocarboxylic acid transporter | 重庆医药工业研究院有限责任公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-109320509-B | FXR receptor agonists | 轩竹生物科技股份有限公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-108602811-B | FXR receptor agonists | 轩竹生物科技有限公司 | 2021-11-16 | — | — | CN | disclosed |
| CN-108558842-B | Pyrimidine derivative anaplastic lymphoma kinase inhibitor | 山东轩竹医药科技有限公司 | 2021-06-04 | — | — | CN | disclosed |
| CN-107108586-B | Polycyclic anaplastic lymphoma kinase inhibitors | 山东轩竹医药科技有限公司 | 2020-07-10 | — | — | CN | disclosed |
| CN-105524045-B | Tetracyclic anaplastic lymphoma kinase inhibitors | 山东轩竹医药科技有限公司 | 2020-04-10 | — | — | CN | disclosed |
| EP-3202765-B1 | POLYCYCLIC ANAPLASTIC LYMPHOMA KINASE INHIBITOR | HAINAN XUANZHU PHARMA CO LTD (CN) | 2020-03-25 | — | — | EP | disclosed |
| US-10011592-B2 | Polycyclic inhibitor of anaplastic lymphoma kinase | Xuanzhu Pharma Co., Ltd. (CN) | 2018-07-03 | — | — | US | disclosed |
| US-20180086745-A9 | POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE | Xuanzhu Biopharmaceutical Co., Ltd. (CN) | 2018-03-29 | — | — | US | disclosed |
| US-20170240534-A1 | POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE | XUANZHU PHARMA CO LTD (CN) | 2017-08-24 | — | — | US | disclosed |
| EP-0634171-B1 | PHARMACEUTICAL COMPOSITION FOR TREATING CEREBRAL THROMBOSIS | TEIJIN LTD (JP) | 1999-05-06 | — | — | EP | disclosed |
| EP-0761225-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING PERIPHERAL CIRCULATION DISORDER | TEIJIN LIMITED (JP) | 1997-03-12 | — | — | EP | disclosed |
| US-5610182-A | ADMINISTERING AN ISOCARBACYCLIN OF SPECIFIC STRUCTURE IN THE FORM OF A FAT EMULSION | TEIJIN, LIMITED (JP) | 1997-03-11 | — | — | US | disclosed |
| EP-0693284-A1 | PROSTACYCLIN-CONTAINING OLEAGINOUS OINTMENT | TEIJIN LIMITED (JP) | 1996-01-24 | — | — | EP | disclosed |
| EP-0634171-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING CEREBRAL THROMBOSIS | TEIJIN LIMITED (JP) | 1995-01-18 | — | — | EP | disclosed |
| US-5116862-A | Acetylenic trithiabicyclo(2.2.2)octanes | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-05-26 | — | — | US | disclosed |
| US-4191771-A | NARCOTIC ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1980-03-04 | — | — | US | disclosed |
| US-4175197-A | 1,3,4-Trisubstituted-4-aryl-1,4,5,6-tetra-hydropyridines | ELI LILLY AND COMPANY (US) | 1979-11-20 | — | — | US | disclosed |
| US-4115400-A | 1-Azoniabicyclo[3.1.0]hexanes | ELI LILLY AND COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
| US-4081450-A | 1,3,4-Trisubstituted-4-arylpiperidines and their preparation | ELI LILLY AND COMPANY (US) | 1978-03-28 | — | — | US | disclosed |