Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1017249 | 1.00 | EGFR (0.77) | EGFRFGFR1CCNA2CDK2CCNA1 | |
| SCHEMBL1069327 | 0.99 | EGFR (0.76) | EGFRFGFR1CCNA2CDK2CCNA1 | |
| SCHEMBL1069330 | 0.99 | EGFR (0.76) | EGFRFGFR1CCNA2CDK2CCNA1 | |
| SCHEMBL1013904 | 0.93 | EGFR (0.88) | EGFRFGFR1 | |
| SCHEMBL1013905 | 0.93 | EGFR (0.88) | EGFRFGFR1 | |
| SCHEMBL1018190 | 0.92 | EGFR (0.87) | EGFRFGFR1 | |
| SCHEMBL1018188 | 0.92 | EGFR (0.87) | EGFRFGFR1 | |
| SCHEMBL938937 | 0.91 | EGFR (0.88) | EGFRFGFR1 | |
| SCHEMBL938936 | 0.91 | EGFR (0.88) | EGFRFGFR1 | |
| SCHEMBL1082325 | 0.91 | EGFR (0.79) | EGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001890-B1 | TETRAHYDROPYRIDOTHIENOPYRIMIDINE COMPOUNDS AND USE FOR THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | BAYER SCHERING PHARMA AG (DE) | 2011-01-12 | — | — | EP | disclosed |