Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 20/20 | 0.84 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10174643 | 0.93 | PIK3CG (0.87) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142087 | 0.92 | PIK3CG (0.82) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142086 | 0.92 | PIK3CG (0.82) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142454 | 0.91 | PIK3CG (1.00) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142223 | 0.91 | PIK3CG (0.80) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142097 | 0.91 | PIK3CG (0.80) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142467 | 0.90 | PIK3CG (0.85) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142195 | 0.90 | PIK3CG (0.79) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142128 | 0.90 | PIK3CG (0.79) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142100 | 0.90 | PIK3CG (1.00) | PIK3CGPRKDCPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040950-A1 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040950-A1 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | PIK3CD, PIK3CA, PIK3R5 | PIK3CG 4/4885PRKDC 82/4885PIK3CD 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.