Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 7/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 13/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9917812 | 0.92 | PRKCQ (0.47) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL9918010 | 0.91 | PRKCE (0.50) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL9917811 | 0.88 | PRKCE (0.49) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL9918008 | 0.84 | PRKCQ (0.46) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL9917781 | 0.83 | PRKCQ (0.48) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL9917774 | 0.76 | PRKCQ (0.51) | PRKCQJAK2ROCK2PRKCDROCK1 | |
| SCHEMBL9917817 | 0.76 | PRKCE (0.62) | PRKCQPRKCECYP2D6CYP3A4 | |
| SCHEMBL9917803 | 0.76 | PRKCE (0.62) | PRKCQPRKCECYP2D6CYP3A4 | |
| SCHEMBL9917921 | 0.76 | PRKCE (0.52) | PRKCQPRKCECYP2D6CYP3A4 | |
| SCHEMBL9917785 | 0.75 | PRKCQ (0.63) | PRKCQJAK2ROCK2PRKCDROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173635-B2 | Kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-08 | — | — | US | disclosed |