Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.50 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.50 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 11/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 10/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 10/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15214876 | 0.84 | ADORA2A (0.54) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL2477008 | 0.83 | CDK1 (0.57) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL10227480 | 0.81 | ADORA2A (0.50) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL12775439 | 0.74 | ADORA2A (0.60) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL784393 | 0.69 | ADORA2A (0.66) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL31331738 | 0.67 | ADORA2A (0.64) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL12141941 | 0.67 | ADORA2A (0.64) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL18751223 | 0.67 | ADORA2A (0.64) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL754007 | 0.67 | ADORA2A (1.00) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL2475932 | 0.67 | ADORA2A (0.64) | PI4KAPI4K2BPI4K2API4KBADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067928-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-8232273-B2 | Heterocyclic compounds and methods of use | GENENTECH, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-20120184541-A1 | COMPOUNDS AND METHODS OF USE | ABBVIE INC. | 2012-07-19 | — | — | US | disclosed |
| US-8114893-B2 | Compounds and methods of use | GENENTECH, INC. (US) | 2012-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184541-A1 | COMPOUNDS AND METHODS OF USE | BCL2A1, BCL2, BAX | PI4KA 4673/4885PI4K2B 3054/4885PI4K2A 3715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.