Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.55 |
| ▸ | BTK | Q06187 | 6/20 | 0.55 |
| ▸ | PAK4 | O96013 | 2/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | TTK | P33981 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018883 | 0.85 | JAK3 (0.55) | JAK3BTKPAK4EGFRPTK2 | |
| SCHEMBL1018882 | 0.84 | JAK3 (0.53) | JAK3BTKPAK4IRAK4EGFR | |
| SCHEMBL4380199 | 0.84 | SYK (0.66) | JAK3BTKPAK4IRAK4SYK | |
| SCHEMBL27912565 | 0.84 | SYK (0.61) | JAK3BTKPAK4IRAK4SYK | |
| SCHEMBL12085415 | 0.84 | JAK3 (0.58) | JAK3BTKPAK4IRAK4SYK | |
| SCHEMBL1015141 | 0.80 | PAK4 (0.59) | JAK3BTKPAK4EGFRTTK | |
| SCHEMBL12085313 | 0.79 | JAK3 (0.70) | JAK3BTKPAK4IRAK4SYK | |
| SCHEMBL12085413 | 0.79 | JAK3 (0.66) | JAK3BTKPAK4IRAK4SYK | |
| SCHEMBL1016206 | 0.78 | TTK (0.49) | JAK3BTKSYKEGFRPTK2 | |
| SCHEMBL1021471 | 0.78 | PTK2 (0.47) | JAK3BTKSYKEGFRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |