Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13277010 | 0.82 | HPGD (0.47) | HPGDALDH1A1LMNATSHRMAPT | |
| SCHEMBL1442220 | 0.82 | KMT2A (0.51) | MCHR1HTR2CSIRT2ALDH1A1TRPV1 | |
| SCHEMBL12811787 | 0.82 | HTR2C (0.51) | MCHR1HTR2CHPGDALDH1A1LMNA | |
| SCHEMBL12811792 | 0.79 | HCRTR1 (0.51) | HCRTR1HCRTR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL12811795 | 0.74 | JAK2 (0.52) | NR1H4HCRTR1HCRTR2ALDH1A1LMNA | |
| SCHEMBL1442554 | 0.74 | LRRK2 (0.47) | HPGDALDH1A1LMNATSHRKMT2A | |
| SCHEMBL1442507 | 0.74 | EGFR (0.50) | NR1H4ALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL12812454 | 0.74 | HPGD (0.53) | HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13276227 | 0.74 | PDE10A (0.44) | HPGDCYP3A4SMN1; SMN2 | |
| SCHEMBL12812024 | 0.73 | NPC1 (0.57) | ALDH1A1LMNAMAPTKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473498-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | Bayer Pharma Aktiengesellschaft (DE) | 2012-07-11 | — | — | EP | claimed |