SCHEMBL10179849

SCHEMBL10179849

C#CCOC(=O)CC(c1cc(Cl)cc(Cl)c1)C(C#N)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.36
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
KDM4E B2RXH2 2/20 0.35
MAPT P10636 2/20 0.35
GAA P10253 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
TACR1 P25103 2/20 0.35
ALDH1A1 P00352 5/20 0.35
TAAR1 Q96RJ0 1/20 0.35
CACNA2D1 P54289 1/20 0.34
CACNA1B Q00975 1/20 0.34
CACNB1 Q02641 1/20 0.34
LMNA P02545 1/20 0.34
TSHR P16473 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10180448 0.90 KMT2A (0.35) NPC1MEN1KMT2AKDM4ENPSR1
SCHEMBL11439369 0.86 TACR1 (0.40) MEN1KMT2AMAPTNPSR1TACR1
SCHEMBL10180840 0.83 KCNA5 (0.43) MEN1KMT2AKDM4EMAPTGAA
SCHEMBL11153133 0.81 MEN1 (0.42) MEN1KMT2AKDM4EMAPTTACR1
SCHEMBL2041881 0.79 KMT2A (0.34) KMT2ANPSR1ALDH1A1LMNAGSTP1
SCHEMBL10179847 0.79 KCNA5 (0.40) MEN1KMT2AKDM4EMAPTGAA
SCHEMBL11153291 0.78 ESR1 (0.35) NPC1MEN1KMT2AKDM4EMAPT
SCHEMBL11155181 0.76 MEN1 (0.45) MEN1KMT2AKDM4EMAPTTACR1
SCHEMBL11161702 0.76 KMT2A (0.36) MEN1KMT2AKDM4EMAPTGAA
SCHEMBL2330078 0.75 POLB (0.35) NPC1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2474226-A1 Herbicidally active composition comprising cyanobutyrates BASF SE (DE) 2012-07-11 EP disclosed
EP-2474226-A1 Herbicidally active composition comprising cyanobutyrates BASF SE (DE) 2012-07-11 EP disclosed