Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.62 |
| ▸ | JAK1 | P23458 | 13/20 | 0.62 |
| ▸ | JAK3 | P52333 | 9/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.54 |
| ▸ | TYK2 | P29597 | 6/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 3/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.52 |
| ▸ | PAK4 | O96013 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | LTK | P29376 | 2/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13695658 | 0.91 | JAK2 (0.69) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL16692526 | 0.90 | JAK2 (0.61) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL12251377 | 0.89 | JAK2 (0.60) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL101611 | 0.89 | JAK2 (0.59) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL101325 | 0.88 | JAK2 (0.58) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL21975118 | 0.88 | JAK2 (0.58) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL21974416 | 0.88 | JAK2 (0.60) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL18599507 | 0.88 | JAK2 (0.58) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL12505740 | 0.88 | JAK2 (0.58) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL29540693 | 0.88 | JAK2 (0.58) | JAK2JAK1JAK3HDAC6TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2474545-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-07-11 | — | — | EP | disclosed |