Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.46 |
| ▸ | DPP4 | P27487 | 6/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365418 | 1.00 | HPGD (0.51) | HPGDKMT2AMEN1MMP1MMP3 | |
| SCHEMBL13267430 | 1.00 | HPGD (0.51) | HPGDKMT2AMEN1MMP1MMP3 | |
| SCHEMBL12324842 | 1.00 | HPGD (0.51) | HPGDKMT2AMEN1MMP1MMP3 | |
| SCHEMBL371088 | 1.00 | HPGD (0.51) | HPGDKMT2AMEN1MMP1MMP3 | |
| Hydrochloric Acid SCHEMBL295178 | 0.99 | HPGD (0.50) | HPGDKMT2AMEN1MMP1MMP3 | |
| SCHEMBL3299190 | 0.84 | HPGD (0.50) | HPGDHTTALDH1A1DPP7DPP4 | |
| SCHEMBL3300519 | 0.84 | HPGD (0.50) | HPGDHTTALDH1A1DPP7DPP4 | |
| SCHEMBL368344 | 0.84 | HPGD (0.50) | HPGDHTTALDH1A1DPP7DPP4 | |
| SCHEMBL3303393 | 0.84 | HPGD (0.50) | HPGDHTTALDH1A1DPP7DPP4 | |
| SCHEMBL10301471 | 0.84 | HPGD (0.50) | HPGDHTTALDH1A1DPP7DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841743-B1 | 3-Aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immuno stimulant activity | ALLERGAN INC (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2474534-B1 | 3-Aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immunostimulant activity | ALLERGAN INC (US) | 2015-07-29 | — | — | EP | disclosed |
| EP-2489658-A1 | 3-Heteroaryl-3-hydroxy-2-amino-propyl amines and related compounds having analgesic and/or immuno stimulant activity | Allergan, Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-2474534-A1 | 3-Aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immunostimulant activity | Allergan, Inc. (US) | 2012-07-11 | — | — | EP | disclosed |