Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | OSBP | P22059 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806903 | 0.85 | BACE1 (0.42) | APPMAPTMAOBPTPN1BACE1 | |
| SCHEMBL806715 | 0.85 | PTPN1 (0.39) | APPMAPTMAOBPTPN1BACE1 | |
| SCHEMBL15980405 | 0.84 | BACE1 (0.41) | APPMAPTMAOBPTPN1BACE1 | |
| SCHEMBL15978362 | 0.80 | APP (0.42) | APPMAPTMAOBPTPN1BACE1 | |
| SCHEMBL1586709 | 0.77 | PPARG (0.49) | OSBPPPARGPPARAACHE | |
| SCHEMBL1586707 | 0.77 | PPARG (0.49) | OSBPPPARGPPARAACHE | |
| SCHEMBL15978364 | 0.77 | APP (0.44) | APPMAPTMAOBPTPN1BACE1 | |
| SCHEMBL1587330 | 0.76 | PPARG (0.48) | MAOBOSBPPPARGPPARA | |
| SCHEMBL8009534 | 0.76 | BACE1 (0.53) | MAOBBACE1PPARGPPARAPPARD | |
| SCHEMBL8011290 | 0.76 | PPARG (0.48) | MAOBOSBPPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037069-A2 | UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-03-22 | — | — | WO | disclosed |