Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.62 |
| ▸ | ACVRL1 | P37023 | 7/20 | 0.62 |
| ▸ | RET | P07949 | 4/20 | 0.62 |
| ▸ | ROS1 | P08922 | 4/20 | 0.62 |
| ▸ | MET | P08581 | 2/20 | 0.62 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
| ▸ | HEXA | P06865 | 1/20 | 0.39 |
| ▸ | HEXB | P07686 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL439680 | 0.89 | NTRK1 (0.61) | NTRK1ACVRL1RETROS1MET | |
| Hydrochloric Acid SCHEMBL3469036 | 0.88 | NTRK1 (0.60) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL10283981 | 0.84 | NTRK1 (0.46) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL773256 | 0.83 | NTRK1 (0.55) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL773254 | 0.82 | NTRK1 (0.45) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL451477 | 0.80 | NTRK1 (0.58) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL439960 | 0.79 | NTRK1 (0.88) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL452357 | 0.79 | NTRK1 (0.88) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL469140 | 0.78 | NPC1 (0.51) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL12136012 | 0.78 | NTRK1 (0.50) | NTRK1ACVRL1RETROS1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065233-A1 | TYROSINE KINASE INHIBITORS | GREGOR VLAD EDWARD (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065233-A1 | TYROSINE KINASE INHIBITORS | ALK, ROS1, ABL1 | NTRK1 65/4885ACVRL1 592/4885RET 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.