Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12946922 | 0.94 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1PKMHPGD | |
| SCHEMBL3460501 | 0.94 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1PKMHPGD | |
| SCHEMBL966006 | 0.93 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AMEN1PKMHPGD | |
| SCHEMBL964362 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2KMT2AMEN1PKMHPGD | |
| SCHEMBL3459376 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AMEN1PKMHPGD | |
| SCHEMBL964825 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AMEN1PKMHPGD | |
| SCHEMBL12946908 | 0.90 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AMEN1PKMHPGD | |
| SCHEMBL10181417 | 0.90 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2AMEN1PKMHPGD | |
| SCHEMBL12915851 | 0.90 | CA1 (0.46) | SMN1; SMN2KMT2AMEN1PKMHPGD | |
| SCHEMBL3459084 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AMEN1PKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |