SCHEMBL10180871

SCHEMBL10180871

CN(C(=O)c1ccc(C(F)(F)F)cc1Cl)c1ccc(Oc2ccc3cc(C(=O)N4CCN(Cc5ccc(OCC(F)F)cc5)CC4)n(C)c3c2)nc1

nearest known ligand 0.55

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
STAT3 P40763 20/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL3064542 0.99 STAT3 (0.54) STAT3
Bromide SCHEMBL3058086 0.93 STAT3 (0.54) STAT3
Hydrochloric Acid SCHEMBL3717664 0.93 STAT3 (0.54) STAT3
Bromide SCHEMBL3066736 0.93 STAT3 (0.60) STAT3
SCHEMBL15295459 0.93 STAT3 (0.55) STAT3
Bromide SCHEMBL3061635 0.92 STAT3 (0.54) STAT3
Bromide SCHEMBL3067953 0.92 STAT3 (0.54) STAT3
Bromide SCHEMBL3046167 0.92 STAT3 (0.54) STAT3
Bromide SCHEMBL3057139 0.91 STAT3 (0.59) STAT3
Bromide SCHEMBL3056400 0.88 STAT3 (0.61) STAT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2207773-B1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF OTSUKA PHARMA CO LTD (JP) 2012-07-11 EP disclosed