SCHEMBL10182092

SCHEMBL10182092

CN(c1ccc(Oc2ccc3cc(C(=O)N4CCN(Cc5ccc(OC(CF)CF)cc5)CC4)n(C)c3c2)nc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
STAT3 P40763 20/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3059677 0.94 STAT3 (0.47) STAT3
SCHEMBL3063838 0.93 STAT3 (0.46) STAT3
SCHEMBL3059802 0.93 STAT3 (0.51) STAT3
SCHEMBL3061391 0.91 STAT3 (0.48) STAT3
SCHEMBL3050131 0.91 STAT3 (0.48) STAT3
SCHEMBL3056418 0.91 STAT3 (0.45) STAT3
SCHEMBL3054990 0.89 STAT3 (0.57) STAT3
SCHEMBL3062238 0.89 STAT3 (0.47) STAT3
SCHEMBL3060972 0.89 STAT3 (0.46) STAT3
SCHEMBL3064278 0.88 STAT3 (0.46) STAT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2207773-B1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF OTSUKA PHARMA CO LTD (JP) 2012-07-11 EP disclosed