Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469138 | 0.85 | PDGFRB (0.40) | NPC1RAB9AAMY1ACBFBKDR | |
| SCHEMBL441275 | 0.82 | RHEB (0.40) | MEN1NPC1RAB9AKMT2ARHEB | |
| SCHEMBL441639 | 0.80 | RHEB (0.45) | MEN1NPC1RAB9AKMT2ARHEB | |
| SCHEMBL10181694 | 0.77 | NTRK1 (0.39) | MEN1NPC1RAB9AKMT2ARHEB | |
| SCHEMBL441643 | 0.70 | RHEB (0.40) | MEN1NPC1RAB9AKMT2ARHEB | |
| SCHEMBL463452 | 0.68 | KDR (0.45) | MEN1NPC1RAB9AKMT2ARHEB | |
| SCHEMBL469140 | 0.68 | NPC1 (0.51) | NPC1RAB9AJAK2TYK2AMY1A | |
| SCHEMBL438749 | 0.67 | RHEB (0.37) | MEN1NPC1RAB9AKMT2ARHEB | |
| SCHEMBL450185 | 0.67 | RHEB (0.37) | MEN1NPC1RAB9AKMT2ARHEB | |
| SCHEMBL438772 | 0.66 | NTRK1 (0.45) | MEN1NPC1RAB9AKMT2ARHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065233-A1 | TYROSINE KINASE INHIBITORS | GREGOR VLAD EDWARD (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065233-A1 | TYROSINE KINASE INHIBITORS | ALK, ROS1, ABL1 | MEN1 3978/4885NPC1 2413/4885RAB9A 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.