Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | BCR | P11274 | 1/20 | 0.59 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.59 |
| ▸ | WEE1 | P30291 | 1/20 | 0.59 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.59 |
| ▸ | ABL2 | P42684 | 1/20 | 0.59 |
| ▸ | FRK | P42685 | 1/20 | 0.59 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.59 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.59 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.59 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | MYLK | Q15746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10235536 | 0.87 | ABL1 (0.64) | BRAFEPHB6ABL1RAF1PDGFRB | |
| SCHEMBL10233722 | 0.85 | ABL1 (0.62) | BRAFEPHB6ABL1RAF1PDGFRB | |
| SCHEMBL13472918 | 0.82 | ABL1 (0.64) | BRAFEPHB6ABL1RAF1PDGFRB | |
| SCHEMBL10235192 | 0.80 | BRAF (0.58) | BRAFEPHB6ABL1RAF1PDGFRB | |
| SCHEMBL10235570 | 0.80 | ABL1 (0.66) | BRAFEPHB6ABL1RAF1PDGFRB | |
| SCHEMBL10235195 | 0.80 | BRAF (0.66) | BRAFEPHB6ABL1RAF1PDGFRB | |
| SCHEMBL10235198 | 0.80 | MAPK14 (0.62) | BRAFEPHB6ABL1RAF1PDGFRB | |
| SCHEMBL10235563 | 0.79 | ABL1 (0.76) | BRAFEPHB6ABL1RAF1PDGFRB | |
| SCHEMBL10233628 | 0.79 | BRAF (0.59) | BRAFEPHB6ABL1RAF1PDGFRB | |
| SCHEMBL10235191 | 0.79 | BRAF (0.59) | BRAFEPHB6ABL1RAF1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2012-02-16 | — | — | US | disclosed |
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | BRAF 1/4885EPHB6 1763/4885ABL1 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.