Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30019623 | 0.89 | HSD17B10 (0.58) | USP2NPSR1NPC1MEN1KMT2A | |
| SCHEMBL27347893 | 0.89 | HSD17B10 (0.58) | USP2NPSR1NPC1MEN1KMT2A | |
| SCHEMBL29165122 | 0.89 | HSD17B10 (0.58) | USP2NPSR1NPC1MEN1KMT2A | |
| SCHEMBL23559008 | 0.88 | NPSR1 (0.70) | NPSR1NPC1MEN1KMT2ALMNA | |
| SCHEMBL1752674 | 0.87 | NPC1 (0.65) | USP2NPSR1NPC1MEN1KMT2A | |
| SCHEMBL6452966 | 0.87 | NPC1 (0.78) | USP2NPSR1NPC1MEN1KMT2A | |
| SCHEMBL15586684 | 0.87 | NPC1 (0.65) | USP2NPSR1NPC1MEN1KMT2A | |
| SCHEMBL29639973 | 0.87 | NPC1 (0.71) | NPSR1NPC1MEN1KMT2ALMNA | |
| SCHEMBL2525285 | 0.86 | NPC1 (0.77) | NPSR1NPC1MEN1KMT2ALMNA | |
| SCHEMBL2389717 | 0.86 | NPC1 (0.77) | NPSR1NPC1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |