Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.59 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.59 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.59 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL471040 | 0.89 | GRIN2D (0.58) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL471034 | 0.86 | GRIN2D (0.46) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL1721600 | 0.78 | GRIN2D (0.55) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7908962 | 0.77 | GRIN2D (0.54) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7899516 | 0.77 | GRIN2D (0.63) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL9662171 | 0.73 | GAA (0.47) | KDM4EGAAALDH1A1PDE3BPDE3A | |
| SCHEMBL29115437 | 0.70 | GRIA1 (0.69) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL9316198 | 0.69 | MAPT (0.41) | KDM4EGLAGAAMAPTALDH1A1 | |
| SCHEMBL23021147 | 0.68 | MAPT (0.49) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL5368743 | 0.68 | PARP1 (0.63) | KDM4EGLAGAAMAPTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404922-A1 | QUINOXALINE COMPOUNDS | Astellas Pharma Inc. (JP) | 2012-01-11 | — | — | EP | disclosed |