Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 4/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CCND1 | P24385 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 2/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909213 | 0.93 | PDE9A (0.43) | PDE9APDE5APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7896957 | 0.88 | PDE9A (0.41) | PDE9APDE5APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL12044672 | 0.86 | PDE9A (0.46) | PDE9APDE5ANOTUMCDK4CCND1 | |
| SCHEMBL1722606 | 0.86 | PDE9A (0.42) | PDE9APDE5AALDH1A1PDK1PDK2 | |
| SCHEMBL7905610 | 0.84 | PDE9A (0.44) | PDE9APDE5APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL15103370 | 0.82 | PDE9A (0.46) | PDE9APDE5APDE1APDE1BPDE1C | |
| SCHEMBL15103337 | 0.82 | PDE9A (0.44) | PDE9APDE5APDE1APDE1BPDE1C | |
| SCHEMBL12044752 | 0.81 | PDE9A (0.43) | PDE9APDE5ANOTUMCDK4CCND1 | |
| SCHEMBL7896964 | 0.81 | PDE9A (0.40) | PDE9APDE5ANOTUMBRD4PDE1A | |
| SCHEMBL7900285 | 0.81 | PDE9A (0.44) | PDE9APDE5APOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404922-A1 | QUINOXALINE COMPOUNDS | Astellas Pharma Inc. (JP) | 2012-01-11 | — | — | EP | disclosed |